"In 2006, researchers at Kyoto University in Japan identified conditions that would allow specialized adult cells to be genetically "reprogrammed" to assume a stem cell-like state. These adult cells, called induced pluripotent stem cells (iPSCs), were reprogrammed to an embryonic stem cell-like state by introducing genes important for maintaining the essential properties of embryonic stem cells (ESCs). Since this initial discovery, researchers have rapidly improved the techniques to generate iPSCs, creating a powerful new way to "de-differentiate" cells whose developmental fates had been previously assumed to be determined."
from Goldthwaite, CA. 2006. The promise of induced pluripotent stem cells (iPSCs). In: Department of Health and Human Services. Regenerative Medicine. [accessed 2018 Oct 25]. https://stemcells.nih.gov/info/Regenerative_Medicine/2006Chapter10.htm.
Transcription Factors
Keratinocytes
Fibroblasts
c-Myc
Disease Modeling
Transplant
Drug Development
Regenerative Medicine